Offering a prime location 4.5 km from the Artistic Village Contemporary Art, the 2-star Despina Hotel Afantou has a private art gallery. Featuring 7 rooms with views of the garden, the hotel is within a few blocks of the Greek dancing.

The centre of Afantou can be reached within a 20-minute walk. The Fort of St. Nicholas is 25 minutes' stroll from the Despina Afantou, while Golf bus stop is 150 metres away. Nature lovers will appreciate the proximity to Traganou Beach, which is 0.7 km away. Along with other cultural attractions Rodos Nature Museum is nestled 15 minutes by car from this comfortable hotel.

The rooms at the property provide guests with complimentary Wi-Fi and a flat-screen TV with satellite channels, as well as comforts such as air conditioning. There is also a private bathroom.

Despina Hotel offers a continental breakfast daily. The outdoor bar offers a variety of light drinks, along with a variety of snacks and a barbecue. Guests can try Greek dishes at Golfer Restaurant situated around 600 metres away.