Situated 1.9 km from Fort of St. Nicholas, Despina Hotel Afantou offers a private art gallery. Offering 7 rooms, the hotel provides a swimming pool as well.

The centre of Afantou is a 20 minutes' walk of this 2-star hotel. Anthony Quinn Bay is just a few steps from the property, while Golf bus stop is about 400 metres away. Nature lovers will appreciate the proximity to Traganou Beach, which is 1.1 km away. Astronomy Cafe is a 10-minute drive from the Despina. For those travelling from afar, Diagoras airport is 27 minutes' drive away.

The rooms at this hotel provide guests with a flat-screen TV with satellite channels, as well as comforts such as air conditioning. Private bathrooms feature a separate toilet and a shower. Guests can also enjoy sea views.

Despina Hotel includes a dining area that is open for a continental breakfast. The bar's menu includes a snack menu and a barbeque as well as light drinks. This property is within a few blocks of The Hidden Garden, that serves Greek cuisine.